An abnormal absence of menstruation.
- While still a student, he published a number of papers, notably on peritonitis, amenorrhea, and liver disease.
- Most of the women who took part in the study reported a history of amenorrhea - absence of a menstrual period for three months or more - before they were later diagnosed with premature ovarian failure.
- Early pregnancy was defined as a period of amenorrhea in a pregnant woman not exceeding 16 weeks.
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