Definition of centromere in English:

Share this entry


Pronunciation: /ˈsentrəˌmir/


The region of a chromosome to which the microtubules of the spindle attach, via the kinetochore, during cell division.
Example sentences
  • In fact, we did not find any informative marker in the three chromosomal divisions around the centromere of this chromosome.
  • The presence of a kinetochore spot indicates the centromere region of each chromosome.
  • We conclude that chromosomes with damaged centromeres fail to correctly attach to the spindle, thus producing MN and monosomy.



Pronunciation: /ˌsentrəˈmi(ə)rik/ Pronunciation: /-ˈmerik/
Example sentences
  • Strains were transformed with a control centromeric plasmid or a centromeric plasmid carrying the wild-type GUK1 gene.
  • In Drosophila, relocation of a euchromatic gene near centromeric or telomeric heterochromatin often leads to its mosaic silencing.
  • In addition, binding of the yeast CBF3 kinetochore complex to centromeric DNA was severely compromised in this mutant.


Early 20th century (originally denoting a region within the oocyst of a malaria parasite): from Latin centrum (see center) + Greek meros 'part'. The current sense dates from the 1930s.

For editors and proofreaders

Syllabification: cen·tro·mere

Share this entry

What do you find interesting about this word or phrase?

Comments that don't adhere to our Community Guidelines may be moderated or removed.