Definition of cyclic GMP in English:

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cyclic GMP

(abbreviation cGMP)


A cyclic version of the nucleotide guanosine monophosphate. In cellular metabolism, it is a secondary messenger affecting cell growth and division.
Example sentences
  • The carbon monoxide activates the enzyme guanylyl cyclase, as does nitric oxide, regulating the intracellular levels of the second messenger cyclic GMP, which in turn regulates cellular activity.
  • A second messenger of internal cellular communication - cyclic GMP, produced in response to nitric oxide - is a key regulator of vascular smooth muscle cell contractility, growth, and differentiation.
  • The resulting vasodilation has been potentially attributed to inhibition of cyclic nucleotide phosphodiesterases, with resulting increases in intracellular levels of cyclic AMP and cyclic GMP accompanied by decreases in Ca.

For editors and proofreaders

Syllabification: cy·clic GMP

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