A cyclic version of the nucleotide guanosine monophosphate. In cellular metabolism, it is a secondary messenger affecting cell growth and division.
- The carbon monoxide activates the enzyme guanylyl cyclase, as does nitric oxide, regulating the intracellular levels of the second messenger cyclic GMP, which in turn regulates cellular activity.
- A second messenger of internal cellular communication - cyclic GMP, produced in response to nitric oxide - is a key regulator of vascular smooth muscle cell contractility, growth, and differentiation.
- The resulting vasodilation has been potentially attributed to inhibition of cyclic nucleotide phosphodiesterases, with resulting increases in intracellular levels of cyclic AMP and cyclic GMP accompanied by decreases in Ca.
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