Definition of dedifferentiate in English:
verb[no object] Biology
(Of a cell or tissue) undergo a reversal of differentiation and lose specialized characteristics.
- For example, they found that the proliferating cells dedifferentiated, meaning they temporarily lost the characteristics of mature heart muscle cells and reverted to a more fetal type of proliferating cell.
- By manipulating niche signals, they could make the stem cells differentiate, then dedifferentiate again.
- The search for compounds to differentiate and dedifferentiate (specialize and despecialize) stem cells is accelerating due to advances in biotechnology for growing and screening cells.
- Example sentences
- This probably reflects the presence of stem cells in the nail bud rather than cell dedifferentiation.
- Our case could be an example of such a dedifferentiation.
- In the presented tumor, there was no indication for dedifferentiation.
Definition of dedifferentiate in:
- British & World English dictionary
What do you find interesting about this word or phrase?
Comments that don't adhere to our Community Guidelines may be moderated or removed.
Most popular in the US
Most popular in the UK
Most popular in Canada
Most popular in Australia
Most popular in Spain
Most popular in Malaysia
Most popular in Pakistan