Inflammation of the esophagus.
- All patients underwent endoscopy before randomization, and those with severe esophagitis, peptic ulcer disease, Barrett's esophagus or other serious conditions were excluded from the study.
- The second group was recruited for histologic comparison and consisted of patients undergoing endoscopy for dyspepsia who had no evidence of esophagitis, ulcer disease or cancer.
- The close association between hiatus hernia and the symptoms of reflux esophagitis, observed long ago, led to the belief that such hernias cause reflux.
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