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gnotobiotic Syllabification: gno·to·bi·ot·ic
Pronunciation: /ˌnōdōbīˈädik/

Definition of gnotobiotic in English:


Of, relating to, or denoting an environment for rearing or culturing organisms in which all the microorganisms are either known or excluded.
Example sentences
  • The March 30th issue of the Proceedings of the National Academy of Sciences, with a Warholian zebrafish cover, features a study from Washington U. where the fish were raised under strictly aseptic (gnotobiotic) conditions.
  • Recently, however, model systems for examination of the intestinal flora have been made available in the establishment of germ-free, gnotobiotic (known flora) and specific pathogen-free animals.
  • The MUSC Gnotobiotic Research Resource gives investigators at MUSC a unique opportunity to conduct research with germfree (gnotobiotic) animal models, in addition to more widely available specific-pathogen-free animal models.


1940s: from Greek gnōtos 'known' + biotic.

Definition of gnotobiotic in:
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