Relating to or denoting an environment for rearing or culturing organisms in which all the microorganisms are either known or excluded.
- The March 30th issue of the Proceedings of the National Academy of Sciences, with a Warholian zebrafish cover, features a study from Washington U. where the fish were raised under strictly aseptic (gnotobiotic) conditions.
- Recently, however, model systems for examination of the intestinal flora have been made available in the establishment of germ-free, gnotobiotic (known flora) and specific pathogen-free animals.
- The MUSC Gnotobiotic Research Resource gives investigators at MUSC a unique opportunity to conduct research with germfree (gnotobiotic) animal models, in addition to more widely available specific-pathogen-free animal models.
1940s: from Greek gnōtos 'known' + biotic.
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