informal Inject oneself with a narcotic drug.
More example sentences
- Eric was just tired and still a little jacked up on drugs, then they did some therapy and he got even more tired.
- He was still pretty much jacked up on drugs, and the rest of the team had practically left.
- And how else are you going stop a 350 pound guy, all jacked up on drugs?
Definition of jack up in:
- The British & World English dictionary