A lymphokine that causes the destruction of certain cells, especially tumor cells.
- Consider the following study as an example: OZAKI et al. established association of an SNP in the lymphotoxin - gene with susceptibility to myocardial infarction.
- TNF-b (also called lymphotoxin) is characterized by its ability to kill a number of different cell types, as well as the ability to induce terminal differentiation in others.
- Red bars mark the locations of putative immune genes, some of which are labelled (TNF = tumour necrosis factor, LT = lymphotoxin, HSP = heat shock protein, C2 and C4 = complement genes, TAP = antigen peptide transporter)
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