Definition of methotrexate in English:

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Pronunciation: /ˌmeTHəˈtreksāt/


A synthetic compound that interferes with cell growth and is used to treat leukemia and other forms of cancer.
  • Alternative name: 4-amino-10-methylfolic acid; chemical formula: C20H22N8O5.
Example sentences
  • Cancer drugs used for primary bone cancer include methotrexate, doxorubicin, and cisplatin.
  • Treatment may include systemic steroids, intralesional steroid injection, antimalarials, or methotrexate.
  • Antimalarial drugs or immune response modifiers like methotrexate can reduce steroid dose and side effects.


1950s: from meth- (denoting a substance containing methyl groups) + elements of unknown origin.

For editors and proofreaders

Syllabification: meth·o·trex·ate

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