Definition of methotrexate in English:


Syllabification: meth·o·trex·ate
Pronunciation: /ˌmeTHəˈtrekˌsāt


  • A synthetic compound that interferes with cell growth and is used to treat leukemia and other forms of cancer.
    • Alternative name: 4-amino-10-methylfolic acid; chemical formula: C20H22N8O5
    More example sentences
    • Cancer drugs used for primary bone cancer include methotrexate, doxorubicin, and cisplatin.
    • Treatment may include systemic steroids, intralesional steroid injection, antimalarials, or methotrexate.
    • Antimalarial drugs or immune response modifiers like methotrexate can reduce steroid dose and side effects.


1950s: from meth- (denoting a substance containing methyl groups) + elements of unknown origin.

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