A mutation in which a sense codon that corresponds to one of the twenty amino acids specified by the genetic code is changed to a chain-terminating codon.
- The proximity of the nonsense mutation to the start codon indicates that these mutations are null alleles.
- Another mutant isolated from the screen, LPY727, contained a nonsense mutation at amino acid 15.
- Another nonsense mutation at codon 187 is shared by the human, the chimpanzee and the gorilla, so that it is most likely to have occurred in their ancestral species.
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Syllabification: non·sense mu·ta·tion
Definition of nonsense mutation in:
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