Definition of nucleophilic in English:

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nucleophilic

Pronunciation: /ˌn(y)o͞oklēōˈfilik/

adjective

Chemistry
(Of a molecule or group) having a tendency to donate electrons or react at electron-poor sites such as protons. Often contrasted with electrophilic.
Example sentences
  • EO is a direct-acting mutagen that reacts with nucleophilic molecules, including DNA, causing gene mutation and chromosome deletions in somatic cells.
  • Methyl lithium is very reactive and acts as a nucleophilic methylating reagent to electrophilic functional groups, such as ketones.
  • In the case of aldehydes and ketones containing carbonyl groups, the highly nucleophilic Grignard reagent contributes its electron pair to form a bond with the carbon atom.

Derivatives

nucleophile

Pronunciation: /ˈn(y)o͞oklēəˌfīl/
noun
Example sentences
  • The reactions can involve either anionic nucleophiles such as iodide ion or neutral molecules such as amines.
  • In a similar way, both hydroxide ions and water molecules may act as nucleophiles by reacting with alkyl halides to produce alcohols.
  • Unlike hydrocarbon based aromatics, which react most readily with electrophiles, perfluoro-aromatics and heterocyclic ring systems react better with nucleophiles.

For editors and proofreaders

Syllabification: nu·cle·o·phil·ic

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