Definition of pharmacophore in English:
A part of a molecular structure that is responsible for a particular biological or pharmacological interaction that it undergoes.
- This pharmacophore identifies two important hydrogen-bonding interactions at opposite ends of the ligand.
- The phenothiazine ring is a well-known pharmacophore, and chlorpromazine is a prototype of this class of antipsychotic drugs.
- The similar mechanism of action of paclitaxel, the epothilones, discodermolide and eleutherobin has led to the suggestion that these structurally dissimilar substances possess common pharmacophores.
Definition of pharmacophore in:
- British & World English dictionary
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