A chronic disease of unknown cause characterized by the enlargement of lymph nodes in many parts of the body and the widespread appearance of granulomas derived from the reticuloendothelial system.
- It is often idiopathic in origin, but may be associated with multiple sclerosis, sarcoidosis, syphilis, Lyme disease, and ocular lymphoma.
- The etiology of the systemic granulomatous disease sarcoidosis remains obscure.
- Amyloidosis and other infiltrative diseases, including sarcoidosis and haemochromatosis, can cause a restrictive syndrome.
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