Definition of Sistine Chapel in English:

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Sistine Chapel

Pronunciation: /ˈsiˌstēn ˈCHapəl/
A chapel in the Vatican, built in the late 15th century by Pope Sixtus IV, containing a painted ceiling and fresco of the Last Judgment by Michelangelo and also frescoes by Botticelli.

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Syllabification: Sis·tine Chap·el

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