Definition of someone's number is up in English:

someone's number is up

informal The time has come when someone is doomed to die or suffer some other disaster or setback.
[with reference to a lottery number or a number by which one may be identified]
More example sentences
  • Although it must be tempting to tell someone that you love that you love them when you know your number is up, if you also know the true perpetrator of a crime that someone else is suspected of, surely you are duty bound to blurt that out first.
  • It doesn't seem to displace much air hence they have little warning, and once they come in contact with the ‘strings’, their number is up!
  • He has even arranged for his body to be returned to Tibet for a traditional sky burial when his number is up.
See parent entry: number

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Word of the day brannigan
Pronunciation: ˈbranɪg(ə)n
noun
a brawl or violent argument