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spironolactone Syllabification: spi·ro·no·lac·tone
Pronunciation: /ˌspīrənōˈlaktōn/

Definition of spironolactone in English:


A steroid derivative that is an aldosterone antagonist, which promotes sodium excretion and is used in the treatment of certain types of edema and hypertension.
  • Chemical formula: C24H32O4S
Example sentences
  • For example, ACE inhibitors, beta-blockers, ARBs, spironolactone and digoxin are probably not necessary in all patients.
  • Pharmacologic agents used have included hydrochlorothiazide, spironolactone, furosemide, propranolol, or hydralazine.
  • We restricted our analyses to loop diuretics, angiotensin converting enzyme inhibitors, blockers, spironolactone, and digoxin.


1960s: from spiro-1 (sense 2) + lactone, with the insertion of -one.

Definition of spironolactone in:
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