Definition of topoisomerase in English:

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Pronunciation: /ˌtäpōˌīˈsäməˌrās/ Pronunciation: /-ˌrāz/


An enzyme that alters the supercoiled form of a DNA molecule.
Example sentences
  • Taken together, these results indicate that the overexpression of the topoisomerase I gene causes DNA damage that is lethal only in the scaA - background.
  • Among the genes affected by supercoiling are the topoisomerase genes.
  • The clastogenicity of topoisomerase inhibitors is believed to result from the transient stabilization of the topoisomerase enzyme with DNA during the catalytic cycle.


1970s: from Greek topos 'place' + isomer + -ase.

For editors and proofreaders

Syllabification: top·o·i·som·er·ase

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