Definition of tricyclic in English:


Syllabification: tri·cy·clic
Pronunciation: /trīˈsīklik, -ˈsik-


  • (Of an organic compound) having three fused rings of atoms in its molecule.
    More example sentences
    • Quinacrine is a planar tricyclic compound with structural similarities to DMMB, yet it does not absorb red light.
    • In addition, all methyl sulfone containing compounds in the tricyclic class are very poorly bioavailable.
    • Clomipramine was equal to desipramine and both tricyclic agents were superior to placebo for amelioration of hyperactivity.


(usually tricyclics) Medicine Back to top  
  • Any of a class of antidepressant drugs having molecules with three fused rings.
    More example sentences
    • However inspection of comparative studies in fall risk between SSRIs and tricyclics suggest these two antidepressant classes exhibit similar risks of fall.
    • Over half of the prescriptions were for the class antidepressants known as tricyclics, while four out of 10 were for SSRIs.
    • The most commonly prescribed antidepressant medications include the tricyclics and selective serotonin reuptake inhibitors.


late 19th century: from tri- 'three' + Greek kuklos 'circle' + -ic.

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