A condition in which an extra copy of a chromosome is present in the cell nuclei, causing developmental abnormalities.
- The aneuploid embryos detected in the progeny from this cross include trisomies and UPDs of chromosomes 7 and 18.
- Both monosomy and trisomy of specific chromosomes are associated with developmental defects and cancer risk.
- A common type of chromosomal abnormality is called a trisomy.
The most common form of Down syndrome, caused by an extra copy of chromosome number 21.
- Microcephaly can also be caused by the chromosomal disorder, trisomy-21 Down syndrome, and by environmental factors, such as fetal alcohol syndrome and fetal exposure to radiation before 15 weeks gestation.
- Trisomy 21 can be detected in the first few months of pregnancy by amniocentesis.
- The majority (about 94%) of children with Down Syndrome are born with standard Trisomy 21, which is not hereditary.
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