- An inherited metabolic disorder in which certain lipids accumulate in the brain, causing spasticity and death in childhood.More example sentences
- Tay-Sachs disease occurs when the body lacks hexosaminidase A, a protein that helps break down a chemical found in nerve tissue called gangliosides.
early 20th century: from the names of Warren Tay (1843–1927), English ophthalmologist, and Bernard Sachs (1858–1944), American neurologist, who described it in 1881 and 1887 respectively.
More definitions of Tay–Sachs diseaseDefinition of Tay–Sachs disease in:
- The US English dictionary