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X chromosome inactivation

Line breaks: X chromo|some in|acti¦va¦tion

Definition of X chromosome inactivation in English:


[mass noun]
The phenomenon in a female mammal whereby the genes in one of the pair of X chromosomes are silenced, with the result that their effects are equivalent to those in the male, with only a single X chromosome.
Example sentences
  • Epigenetic regulation in aging mammals can be quantitatively measured using genes subject to X chromosome inactivation and genomic imprinting.
  • While X chromosome inactivation specifically affects genes on the X chromosome, genomic imprinting modifies the activity of a subset of autosomal genes in a parent-of-origin-specific manner.
  • In mammals, methylation is required for essential developmental programs including X chromosome inactivation in females and genomic imprinting.

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Word of the day colloquy
Pronunciation: ˈkɒləkwi
a conversation