Denoting or relating to a cell-produced substance that has an effect on the cell by which it is secreted.
- We reasoned that if dopamine is also produced by the alveolar epithelial cells, then it may act as a paracrine or autocrine substance thus contributing to the regulation of lung liquid clearance.
- The amount of ligand that has been released by the autocrine cell in response to the activation is insufficient in this case to sustain signaling.
- In particular, spatially localized autocrine signaling may confer directional persistence to cell migration, as suggested by recent experimental observations.
1980s: from auto-1 + Greek krinein 'to separate'.
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