Definition of biotransformation in English:


Line breaks: bio|trans¦form|ation
Pronunciation: /ˌbʌɪəʊtransfəˈmɛɪʃ(ə)n
, trɑːns-, -nz-/


[mass noun]
  • The alteration of a substance, typically a drug, within the body.
    More example sentences
    • Medication clearance and excretion occur by two major mechanisms: hepatic metabolism or biotransformation and renal excretion.
    • It is unlikely to be a direct effect and is probably a result of biotransformation of the drug in the lung to reactive metabolites and/or oxygen species that damage lung cells.
    • Other recognized factors leading to medication allergy are pre-existing allergies and presence of diseases that interfere with medication biotransformation and excretion.

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