Definition of centromere in English:

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centromere

Pronunciation: /ˈsɛntrə(ʊ)mɪə/

noun

Biology
The region of a chromosome to which the microtubules of the spindle attach, via the kinetochore, during cell division.
Example sentences
  • In fact, we did not find any informative marker in the three chromosomal divisions around the centromere of this chromosome.
  • The presence of a kinetochore spot indicates the centromere region of each chromosome.
  • We conclude that chromosomes with damaged centromeres fail to correctly attach to the spindle, thus producing MN and monosomy.

Derivatives

centromeric

adjective
Example sentences
  • Strains were transformed with a control centromeric plasmid or a centromeric plasmid carrying the wild-type GUK1 gene.
  • In Drosophila, relocation of a euchromatic gene near centromeric or telomeric heterochromatin often leads to its mosaic silencing.
  • In addition, binding of the yeast CBF3 kinetochore complex to centromeric DNA was severely compromised in this mutant.

Origin

Early 20th century (originally denoting a region within the oocyst of a malaria parasite): from Latin centrum (see centre) + Greek meros 'part'. The current sense dates from the 1930s.

For editors and proofreaders

Line breaks: centro|mere

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