The region of a chromosome to which the microtubules of the spindle attach, via the kinetochore, during cell division.
- In fact, we did not find any informative marker in the three chromosomal divisions around the centromere of this chromosome.
- The presence of a kinetochore spot indicates the centromere region of each chromosome.
- We conclude that chromosomes with damaged centromeres fail to correctly attach to the spindle, thus producing MN and monosomy.
- Example sentences
- Strains were transformed with a control centromeric plasmid or a centromeric plasmid carrying the wild-type GUK1 gene.
- In Drosophila, relocation of a euchromatic gene near centromeric or telomeric heterochromatin often leads to its mosaic silencing.
- In addition, binding of the yeast CBF3 kinetochore complex to centromeric DNA was severely compromised in this mutant.
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