Definition of dedifferentiate in English:

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Pronunciation: /ˌdiːdɪfəˈrɛnʃɪeɪt/


[no object] Biology
(Of a cell or tissue) undergo a reversal of differentiation and lose specialized characteristics: some types of human cells dedifferentiate in culture, becoming primitive, unspecialized cells
More example sentences
  • For example, they found that the proliferating cells dedifferentiated, meaning they temporarily lost the characteristics of mature heart muscle cells and reverted to a more fetal type of proliferating cell.
  • By manipulating niche signals, they could make the stem cells differentiate, then dedifferentiate again.
  • The search for compounds to differentiate and dedifferentiate (specialize and despecialize) stem cells is accelerating due to advances in biotechnology for growing and screening cells.



Example sentences
  • This probably reflects the presence of stem cells in the nail bud rather than cell dedifferentiation.
  • Our case could be an example of such a dedifferentiation.
  • In the presented tumor, there was no indication for dedifferentiation.
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