Share this entry
diphenhydramine Line breaks: di|phen|hydra¦mine
Pronunciation: /ˌdʌɪfɛnˈhʌɪdrəmiːn/

Definition of diphenhydramine in English:


[mass noun] Medicine
An antihistamine compound used for the symptomatic relief of allergies.
Example sentences
  • Take an antihistamine containing diphenhydramine (Benadryl, Tylenol Severe Allergy) or chlorpheniramine maleate (Chlor-Trimeton, Teldrin).
  • Amitriptyline, diazepam and diphenhydramine (in Tylenol PM) are considered risky for older individuals.
  • The sedating antihistamine diphenhydramine is found in Benadryl, Tylenol PM and Sominex.


1940s: from diphen- (denoting the presence of two phenyl groups) + hydr- + amine.

Definition of diphenhydramine in:
Share this entry

What do you find interesting about this word or phrase?

Comments that don't adhere to our Community Guidelines may be moderated or removed.

Subscribe to remove adverts and access premium resources