Definition of diphenhydramine in English:

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Pronunciation: /ˌdʌɪfɛnˈhʌɪdrəmiːn/


[mass noun] Medicine
An antihistamine compound used for the symptomatic relief of allergies.
Example sentences
  • Take an antihistamine containing diphenhydramine (Benadryl, Tylenol Severe Allergy) or chlorpheniramine maleate (Chlor-Trimeton, Teldrin).
  • Amitriptyline, diazepam and diphenhydramine (in Tylenol PM) are considered risky for older individuals.
  • The sedating antihistamine diphenhydramine is found in Benadryl, Tylenol PM and Sominex.


1940s: from diphen- (denoting the presence of two phenyl groups) + hydr- + amine.

For editors and proofreaders

Line breaks: di|phen|hydra¦mine

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