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disulfiram Line breaks: disulfiram
Pronunciation: /dʌɪˈsʌlfɪram/

Definition of disulfiram in English:


[mass noun] Medicine
A synthetic compound used in the treatment of alcoholics to make drinking alcohol produce unpleasant after-effects. Also called Antabuse ( trademark).
  • Alternative name: tetraethylthiuram disulphide; chemical formula: (C2H5)2NCSSCN(C2H5)2
Example sentences
  • The rationale for disulfiram in treating alcoholism is that most alcoholics taking disulfiram will not drink for fear of getting sick.
  • Occasionally the modestly toxic disulfiram (Antabuse ®) is useful.
  • Consuming alcohol after taking disulfiram results in symptoms such as palpitations, flushing, nausea, vomiting, and headache.


1940s: blend of disulfide (see disulphide) and thiuram (from thio- + urea + amide).

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