Definition of epistasis in English:

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Pronunciation: /ɪˈpɪstəsɪs/


[mass noun] Genetics
The interaction of genes that are not alleles, in particular the suppression of the effect of one such gene by another.
Example sentences
  • Genetic epistasis of gene expression can also be considered with large sample sizes.
  • For geneticists, epistasis is associated with the limits of the additive model of gene action.
  • These results suggest that future genetic models for the evolution of aging should incorporate the effects of epistasis.



Pronunciation: /ˌɛpɪˈstatɪk/
Example sentences
  • The results suggested that a minimum of two genes with epistatic effects were involved in the genetic control of cleistogamy.
  • Thus, neither allele is epistatic to the other in permitting the occurrence of expansions or contractions.
  • Such sites may be indicative of hotspots of recombination or mutation or epistatic selection.


Early 19th century: from Greek, literally 'stoppage', from ephistanai 'to stop'.

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