Definition of epitope in English:


Line breaks: epi|tope
Pronunciation: /ˈɛpɪtəʊp


  • The part of an antigen molecule to which an antibody attaches itself. Also called antigenic determinant.
    More example sentences
    • On cell-surface glycoproteins, the epitope structure of TF antigen is linked to either serines or threonines.
    • The loci of the known epitopes of the antibodies used are shown diagrammatically in Fig.1.
    • In all the experiments on native titin, the molecule was attached to two beads, each labeled with an antibody to a different epitope.


1960s: from epi- 'upon' + Greek topos 'place'.

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