Share this entry

Share this page

frameshift mutation

Line breaks: frame|shift mu|ta¦tion

Definition of frameshift mutation in English:

noun

Genetics
A mutation caused by the addition or deletion of a base pair or base pairs in the DNA of a gene resulting in the translation of the genetic code in an unnatural reading frame from the position of the mutation to the end of the gene.
Example sentences
  • We estimate that reversion of the lac mutation is about one-tenth as likely as a null frameshift mutation in a typical gene.
  • This frameshift mutation (deletion at positions 1151-1160) could be merely drifting to high frequency due to weak functional constraint.
  • In ORF 2 there is a deletion of 11 nucleotides that causes a frameshift mutation and a premature stop codon; an additional 1 bp insertion is located further downstream.

Share this entry

Share this page

 

What do you find interesting about this word or phrase?

Get more from Oxford Dictionaries

Subscribe to remove adverts and access premium resources

Word of the day prepotent
Pronunciation: prɪˈpəʊt(ə)nt
adjective
greater than others in power or influence