A mutation caused by the addition or deletion of a base pair or base pairs in the DNA of a gene resulting in the translation of the genetic code in an unnatural reading frame from the position of the mutation to the end of the gene.
- We estimate that reversion of the lac mutation is about one-tenth as likely as a null frameshift mutation in a typical gene.
- This frameshift mutation (deletion at positions 1151-1160) could be merely drifting to high frequency due to weak functional constraint.
- In ORF 2 there is a deletion of 11 nucleotides that causes a frameshift mutation and a premature stop codon; an additional 1 bp insertion is located further downstream.
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