Definition of in silico in English:

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in silico

Pronunciation: /ɪn ˈsɪlɪkəʊ/

adjective& adverb

(Of scientific experiments or research) conducted or produced by means of computer modelling or computer simulation: [as adjective]: in silico analysis of the human genome [adverb]: students who are too squeamish to dissect a frog can perform the procedure in silico
More example sentences
  • This in silico approach would be helpful in ranking textile dyes of the different classes based on their binding affinities.
  • In silico strategies can be used to investigate the potential roles of a mutation on, for instance, protein stability.
  • In silico propagation of the charged particles yielded passage time values that are compatible with the measured average passage time of ions.


1980s: Latin, literally 'in silicon' (with reference to the use of silicon chips in computer systems), on the pattern of in vitro and in vivo.

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