Definition of ligation in English:

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Pronunciation: /lɪˈɡeɪʃ(ə)n/


[mass noun]
1The surgical procedure of tying a ligature tightly around a blood vessel or other duct or tube in the body: the ligation of the cystic duct
More example sentences
  • Failure to recognize such aberrant ductal anatomy may lead to potential ligation of ducts during surgery.
  • Treatments vary from radiological ablation to surgical ligation of the varicocele, although most urologists reserve the radiological approach for the rare surgical failures.
  • One hospital transfer is accounted to each of the following procedures: circumcision, cystoscopy, hemorrhoid ligation and vasectomy reversal.
2 Biochemistry The joining of two DNA strands or other molecules by a phosphate ester linkage.
Example sentences
  • A mechanism leading to tandem sequence duplication may involve DNA damage followed by DNA synthesis, strand displacement, and ligation.
  • The ligation reactions were used as template DNA for one of the following methods.
  • The cut DNAs were ligated at low concentrations, to encourage intramolecular ligation reactions.


Late Middle English: from late Latin ligatio(n-), from the verb ligare (see ligate).

For editors and proofreaders

Line breaks: li|ga¦tion

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