Definition of pharmacophore in English:


Line breaks: pharma¦co|phore
Pronunciation: /ˈfɑːməkəˌfɔː


A part of a molecular structure that is responsible for a particular biological or pharmacological interaction that it undergoes.
More example sentences
  • This pharmacophore identifies two important hydrogen-bonding interactions at opposite ends of the ligand.
  • The phenothiazine ring is a well-known pharmacophore, and chlorpromazine is a prototype of this class of antipsychotic drugs.
  • The similar mechanism of action of paclitaxel, the epothilones, discodermolide and eleutherobin has led to the suggestion that these structurally dissimilar substances possess common pharmacophores.

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