A biologically inactive substance which is metabolized into an enzyme.
- Covalent modification of pre-existing pools of inactive proenzymes produces active enzymes.
- These death proteases are part of a proteolytic cascade activating proenzymes into active proteases.
- Protein digestion begins in the stomach, where a proenzyme called pepsinogen is secreted, autocatalytically converted to Pepsin A, and used for the first step of proteolysis.
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