noun[mass noun] Biochemistry
A protein present in blood plasma which is converted into active thrombin during coagulation.
- Contact with tissue factor triggers the coagulation cascade, resulting in the conversion of prothrombin to active thrombin.
- This complex activates prothrombin to thrombin in the presence of calcium ions.
- Years ago we said fibrinogen (a soluble protein) becomes a clot of insoluble fibrin by the action of thrombin made from soluble prothrombin in the presence of calcium.
Definition of prothrombin in:
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