Definition of prozone in English:

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Pronunciation: /ˈprəʊzəʊn/


[mass noun] Medicine
(In testing for antigens) the range of relative quantities of precipitin (or agglutinin) and antigen within which any precipitation (or agglutination) is inhibited by the predominance of one component.
Example sentences
  • In addition, these tests may show a ‘prozone’ phenomenon in which large amounts of antibody block the antibody-antigen reaction, causing a false-negative test in the undiluted sample.
  • However, highly concentrated antibodies may result in a prozone effect, leading to decreased intensity of staining.


Early 20th century: from pro-2 'before' + (agglutination) zone.

For editors and proofreaders

Line breaks: pro|zone

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