noun[mass noun] Medicine
(In testing for antigens) the range of relative quantities of precipitin (or agglutinin) and antigen within which any precipitation (or agglutination) is inhibited by the predominance of one component.
- In addition, these tests may show a ‘prozone’ phenomenon in which large amounts of antibody block the antibody-antigen reaction, causing a false-negative test in the undiluted sample.
- However, highly concentrated antibodies may result in a prozone effect, leading to decreased intensity of staining.
Early 20th century: from pro-2 'before' + (agglutination) zone.
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