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- 1a cat-sized American mammal of the weasel family, with distinctive black-and-white striped fur. When threatened it squirts a fine spray of foul-smelling irritant liquid from its anal glands towards its attacker.
- Mephitis and other genera, family Mustelidae: several species, in particular the striped skunk (M. mephitis)
- 2 informalshort for skunkweed.
verb[with object] North American informal
mid 17th century: from Abnaki segankw; variants occur in many other American Indian dialects