Definition of topoisomerase in English:

Share this entry

topoisomerase

Pronunciation: /ˌtɒpəʊˈʌɪsəməreɪz/

noun

Biochemistry
An enzyme which alters the supercoiled form of a DNA molecule.
Example sentences
  • Taken together, these results indicate that the overexpression of the topoisomerase I gene causes DNA damage that is lethal only in the scaA - background.
  • Among the genes affected by supercoiling are the topoisomerase genes.
  • The clastogenicity of topoisomerase inhibitors is believed to result from the transient stabilization of the topoisomerase enzyme with DNA during the catalytic cycle.

Origin

1970s: from Greek topos 'place' + isomer + -ase.

For editors and proofreaders

Line breaks: topo|isom¦er¦ase

Share this entry
 

What do you find interesting about this word or phrase?

Comments that don't adhere to our Community Guidelines may be moderated or removed.