Definition of voltage clamp in English:

voltage clamp

Line breaks: volt|age clamp
Physiology

noun

  • A constant electrical potential applied to a cell membrane, typically in order to measure ionic currents.
    More example sentences
    • The easiest method of measuring charge transfer across the membrane is the whole-cell voltage clamp because all motor charges in the cell contribute to the signal, making the signal large.
    • Under voltage clamp, we measured the membrane current of isolated photoreceptors with tight-seal electrodes in the whole-cell mode.
    • The lack of expression for a mutant was defined as no currents in a two-electrode voltage clamp from at least three different RNA injections and at least two different clones.

verb

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  • (voltage-clamp) [with object] Apply a voltage clamp to (a membrane, cell, etc.): oocytes were voltage-clamped at −80 to −100 mV
    More example sentences
    • Second, we have designed the circuit to remove series resistance error in voltage-clamping the cell.
    • The cells were voltage-clamped and perfused with an artificial intracellular solution containing 15 mM EGTA to ensure that the bulk of the Ca 2 + mobilized by depolarization is bound to this extrinsic buffer.
    • We cannot experimentally distinguish between this model and the one shown in Fig.8 because this would require performing tracer-flux experiments from a single voltage-clamped cell.

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