1British a woman in charge of domestic and medical arrangements at a boarding school or other institution:she initiated training for matrons of residential homes [as name]:‘This is preposterous,’ sighed Matron
British the woman in charge of the nursing in a hospital (the official term is now senior nursing officer):she had been matron of a Belgian Hospital
US a female prison officer.
2an older married woman, especially one who is staid or dignified:respectable suburban matrons
late Middle English(in sense 2): from Old French matrone, from Latin matrona, from mater, matr- 'mother'