A metabolic disease in which fat distribution in the body becomes abnormal, often as a result of taking protease inhibitor drugs. Fat is lost from the face, arms, and legs, and is built up in other places, especially the breasts, abdomen, and back of the neck.
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- Various definitions of the lipodystrophy syndrome exist and different diagnostic tools are used.
- The evolution of the individual clinical components of the lipodystrophy syndrome is variable.
- The main clinical features of the lipodystrophy syndrome are peripheral fat loss, central fat accumulation and metabolic abnormalities which lead to lactoacidosis.