Sufficiently great or important to be worthy of attention; noteworthy
a significant increase in sales
(In computing and numerical analysis) designating the digit in a number (which may be an address in a computer instruction) having the greatest value, that is, the leftmost digit of a number as conventionally written.
The formal quality in a work of art which provokes an aesthetic response in the viewer, and hence distinguishes the object as art.
Each of the digits of a number that are used to express it to the required degree of accuracy, starting from the first non-zero digit
A person with whom someone has an established romantic or sexual relationship
The bit in a binary number which is of the lowest numerical value
The bit in a binary number which is of the greatest numerical value