Translate Alexandria | into Italian 1the chief port of Egypt; population 4,084,700 (est. 2006). Founded in 332 bc by Alexander the Great, it was a major center of Hellenistic culture, renowned for its library and for the Pharos lighthouse. 2an industrial city in central Louisiana, on the Red River; population 48,639 (est. 2008). 3a city in northern Virginia, on the Potomac River, across from Washington, DC; population 143,885 (est. 2008).