Definition of Lesch–Nyhan syndrome in English:

Lesch–Nyhan syndrome

Syllabification: Lesch–Ny·han syn·drome
Pronunciation: /leSHˈnīhan ˌsindrōm


A rare hereditary disease that affects young boys, usually causing early death. It is marked by compulsive self-mutilation of the head and hands, together with mental retardation and involuntary muscular movements.


1960s: named after Michael Lesch (1939–2008) and William L. Nyhan (1926–), US physicians.

Definition of Lesch–Nyhan syndrome in:

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Word of the day demoralize
Pronunciation: dəˈmôrəˌlīz
cause (someone) to lose confidence or hope; dispirit