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St. Louis Syllabification: St. Lou·is
Pronunciation: /ˈlo͞o-is/ /ˈlo͞o-ē/

Definition of St. Louis in English:

A city and port in eastern Missouri, on the Mississippi River just south of its confluence with the Missouri River; population 354,361 (est. 2008). Founded as a French fur-trading post in the 1760s, it passed to the Spanish, the French again, and finally in 1803 to the US as part of the Louisiana Purchase.

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