Definition of Tay–Sachs disease in English:

Tay–Sachs disease

Syllabification: Tay–Sachs dis·ease
Pronunciation: /ˈtāˈsaks diˌzēz


An inherited metabolic disorder in which certain lipids accumulate in the brain, causing spasticity and death in childhood.
More example sentences
  • Tay-Sachs disease occurs when the body lacks hexosaminidase A, a protein that helps break down a chemical found in nerve tissue called gangliosides.


early 20th century: from the names of Warren Tay (1843–1927), English ophthalmologist, and Bernard Sachs (1858–1944), American neurologist, who described it in 1881 and 1887, respectively.

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