Definition of agonist in English:

agonist

Syllabification: ag·o·nist
Pronunciation: /ˈagənist
 
/

noun

  • 1 Biochemistry A substance that initiates a physiological response when combined with a receptor. Compare with antagonist.
    More example sentences
    • They may mimic naturally occurring steroids, act as hormone receptor agonists or antagonists or alter the enzymes responsible for hormone synthesis and degradation.
    • Medications that can reduce androgen levels include estrogen, gonadotropin-releasing hormone agonists, and glucocorticoids.
    • These observations provide support for the model that glucose and structurally related sugars are agonists of the Gpr1 receptor.
  • 2 Anatomy A muscle whose contraction moves a part of the body directly. Often contrasted with antagonist.
    More example sentences
    • In addition, we believe that the agonist / antagonist muscle ratios are important values when considering how the scapula provides stability, mobility, and symptom-free function.
    • The agonist and antagonist muscles work in concert to create muscular balance in the human body.
    • It's a matter of muscle aesthetics: The upper arm looks best when both its opposing muscle groups, the agonists and antagonists - that's bis and tris to you - carry a complementary amount of muscle.
  • 3 another term for protagonist.
    More example sentences
    • But now, replying to Harapha’s taunts with a startling invitation to combat, Samson is confident as the agonist was never before depicted.
    • To every agonist, there is an antagonist.

Derivatives

agonism

Pronunciation: /-ˌnizəm/
noun
More example sentences
  • Studies have clearly demonstrated that key therapies in the acute attack of migraine share the common pharmacologic activity of serotonin receptor agonism.
  • Rather, all known abused drugs affect a limited number of neurotransmitters by agonism or antagonism of a specific receptor site.
  • An agonist is described as a drug that binds to and activates receptors; the possibility of spontaneous receptor activity and therefore of inverse agonism is not mentioned.

Origin

early 20th century: from Greek agōnistēs 'contestant' (a sense reflected in English in the early 17th century), from agōn 'contest'.

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