Definition of amide in English:


Syllabification: am·ide
Pronunciation: /ˈamīd, -id


  • 1An organic compound containing the group —C(O)NH2, related to ammonia by replacing a hydrogen atom by an acyl group.
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    • On the other hand, the permeability of the membrane for small uncharged solutes such as low molecular weight alcohols, amides, ketones etc., did not change.
    • Nitriles are formed by heating amides with phosphorous pentoxide or by treating organic halogen compounds with sodium cyanide.
    • Primary amides are weakly basic and can form compounds with metals such as sodium, potassium, mercury, and cadmium, although heavy metal amides can be explosive.
  • 1.1A compound derived from ammonia by replacement of a hydrogen atom by a metal, containing the anion NH2-.
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    • Secondary and tertiary amides are prepared by reacting primary amides or nitriles with organic acids.
    • The resulting ester was saponified under basic conditions to the free acid, converted to the acyl chloride with thionyl chloride, and then to the amide with anhydrous ammonia gas.
    • The ester functional group can also be split by ammonia to give amides and alcohols.


mid 19th century: from ammonia + -ide.

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