Definition of amitriptyline in English:


Syllabification: am·i·trip·ty·line
Pronunciation: /ˌamiˈtriptəˌlēn, -lin


  • An antidepressant drug of the tricyclic group, with a mild tranquilizing action.
    More example sentences
    • Tricyclic antidepressants, including amitriptyline, can cause weight gain, drowsiness, and anticholinergic symptoms.
    • The most useful drugs are anticonvulsants, especially gabapentin and carbamazepine, and tricyclic antidepressants, especially amitriptyline.
    • Of the tricyclic antidepressants, amitriptyline appears to be the most efficacious in the treatment of diabetic neuropathy when compared to placebo.


1960s: from ami(ne) + tri- + (he)ptyl + -ine4.

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