Definition of cross-tolerance in English:


Syllabification: cross-tol·er·ance


  • Resistance to the effects of a substance because of exposure to a pharmacologically similar substance: cross-tolerance of barbiturates with alcohol was observed
    More example sentences
    • Because of cross-tolerance, this high tolerance may extend to substances the patient never abused.
    • When convening from one opioid to another, it is recommended that the calculated dose be reduced by 50% to account for incomplete cross-tolerance.
    • When treating acute pain in patients recovering from chemical dependency, the physician must consider the phenomena of cross-tolerance and cross-addiction.

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